1H-Indazol-5-amine → HCID 23366735, compound

HRID 1079355Notes

Reaction equation

HRID 1079355 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]([CH3:14])[CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][N:20]=[CH:19]2>>[ClH:1].[CH3:13][N:12]([CH3:14])[C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][N:20]=[CH:19]2

Participants

3

Reactant 2

HCID 880121H-Indazol-5-amineHCID 233667574-chloro-N,N-dimethylquinazolin-6-amine

Product 1

HCID 23366735HCID 23366735, compoundYield 92%

Procedure

Using an analogous procedure to that described in Example 5, 4-chloro-6-dimethylaminoquinazoline was reacted with 5-amino-1H-indazole to give 6-dimethylamino-4-(1H-indazol-5-ylamino)quinazoline hydrochloride in 92% yield, m.p. >300° C.;

Sources & evidence

ORD record
ord-2b75d16aa4bf4513ab713c6386ed9cab
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

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