1H-Indazol-5-amine → HCID 23366731, compound

HRID 1079356Notes

Reaction equation

HRID 1079356 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][N:22]=[CH:21]2>>[ClH:1].[NH:23]1[C:24]2[C:20](=[CH:19][C:18]([NH:17][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([N:12]5[CH2:16][CH2:15][CH2:14][CH2:13]5)[CH:10]=4)[N:5]=[CH:4][N:3]=3)=[CH:26][CH:25]=2)[CH:21]=[N:22]1

Participants

3

Reactant 2

HCID 880121H-Indazol-5-amineHCID 23366771HCID 23366771, compound

Product 1

HCID 23366731HCID 23366731, compoundYield 78%

Procedure

Using an analogous procedure to that described in Example 5, 4-chloro-6-(1-pyrrolidinyl)quinazoline was reacted with 5-amino-1H-indazole to give 4-(1H-indazol-5-ylamino)-6-(1-pyrrolidinyl)quinazoline hydrochloride in 78% yield, m.p. 271°-273° C.;

Sources & evidence

ORD record
ord-1233e13d3edf43b0b962b3b733462e22
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

Loading…