5-Aminoindole → 7-Fluoro-4-(5-indolylamino)quinazoline hydrochloride

HRID 1079358Notes

Reaction equation

HRID 1079358 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[CH:17]2>>[ClH:1].[F:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[NH:19][CH:18]=[CH:17]4)=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 788675-AminoindoleHCID 162270134-Chloro-7-fluoroquinazoline

Product 1

HCID 233667397-Fluoro-4-(5-indolylamino)quinazoline hydrochlorideYield 65%

Procedure

Using an analogous procedure to that described in Example 5, 4-chloro-7-fluoroquinazoline was reacted with 5-aminoindole to give 7-fluoro-4-(5-indolylamino)quinazoline hydrochloride in 65% yield;

Sources & evidence

ORD record
ord-3594bba023da4897b8c9f50543b50836
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

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