5-Aminoindole → HCID 23366741, compound

HRID 1079359Notes

Reaction equation

HRID 1079359 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[CH:19]2>>[ClH:1].[NH:21]1[C:22]2[C:18](=[CH:17][C:16]([NH:15][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=4)[N:5]=[CH:4][N:3]=3)=[CH:24][CH:23]=2)[CH:19]=[CH:20]1

Participants

3

Reactant 2

HCID 788675-AminoindoleHCID 113562574-Chloro-6-nitroquinazoline

Product 1

HCID 23366741HCID 23366741, compoundYield 53%

Procedure

Using an analogous procedure to that described in Example 5, 4-chloro-6-nitroquinazoline was reacted with 5-aminoindole to give 4-(5-indolylamino)-6-nitroquinazoline hydrochloride in 53% yield, m.p. 300° C.;

Sources & evidence

ORD record
ord-514f04ef90a4407ca46221d2e5809317
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

Loading…