5-Aminoindole → HCID 23366781, compound

HRID 1079361Notes

Reaction equation

HRID 1079361 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[CH:21]2>>[NH:23]1[C:24]2[C:20](=[CH:19][C:18]([NH:17][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([N:12]5[CH2:16][CH2:15][CH2:14][CH2:13]5)[CH:10]=4)[N:5]=[CH:4][N:3]=3)=[CH:26][CH:25]=2)[CH:21]=[CH:22]1

Participants

3

Reactant 2

HCID 788675-AminoindoleHCID 23366771HCID 23366771, compound

Product 1

HCID 23366781HCID 23366781, compoundYield 84%

Procedure

Using an analogous procedure to that described in Example 5, 4-chloro-6-(1-pyrrolidinyl)quinazoline was reacted with 5-aminoindole to give 4-(5-indolylamino)-6-(1-pyrrolidinyl)quinazoline in 84% yield;

Sources & evidence

ORD record
ord-f7b0a5cd9e8740769d091ba8181ebb7f
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

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