Benzyl Bromide → HCID 131719734, compound

Participants

Reaction Steps

415 mg of 4-tert-butylcarbonyl-7α-methoxy-3-methyl-2-(1-methyl-1,2,3,4-tetrazol-5-yl)thio-3-cephem 1,1-dioxide was dissolved in dimethyl sulphoxide (3 ml) and triethylamine (0.153 ml) and benzyl bromide (0.360 ml) were added. The reaction mixture was left overnight at room temperature, diluted with ethyl acetate, washed with a dilute solution of hydrochloric acid and eventually with brine. Drying over Na2SO4 and removal of the organic solvent left a residue which was then purified by flash chromatography affording the title compound as a white solid (270 mg).

Provenance & Evidence