Benzyl Bromide → HCID 88125651, compound

Participants

Reaction Steps

A solution of 2-(6-benzhydryloxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio-4-tert-butylcarbonyl-7α-methoxy-3-methyl-3-cephem 1,1-dioxide (300 mg) in acetonitrile (5 ml) was treated at room temperature with triethylamine (0.067 ml) and benzyl bromide (0.172 ml). After 4 hr, the reaction mixture was diluted with dichloromethane, washed with brine and dried over Na2SO4. The solvent was then removed and the residue purified by flash chromatography, thereby obtaining the title compound as a white solid (180 mg).

Provenance & Evidence