Triethylamine → HCID 131719736, compound

Participants

Reaction Steps

A solution of 4-tert-butylcarbonyl-7α-methoxy-3-methyl-2-(1-methyl-1,2,3,4-tetrazol-5-yl)thio-3-cephem 1,1-dioxide (500 mg) in dimethyl sulphoxide (4 ml) was treated at room temperature with triethylamine (0.185 ml) and benzhydryl-4-bromomethylbenzoate (1.4 g). The solution was stirred for 1 hr, diluted with dichloromethane, washed with brine and eventually dried over Na2SO4. Removal of the solvent left a crude residue which afforded the title compound as a yellowish solid (250 mg) after flash chromatography.

Provenance & Evidence