Ethanol → HCID 23366918, compound

Participants

Reaction Conditions

Reaction Steps

1-Acetyl-4-(4-pyrrolidinopheyloxy)piperidine (1.5 g) obtained in Example 1 was dissolved in a mixed solvent of ethanol (5 ml), water (5 ml) and conc. hydrochloric acid (5 ml), followed by heating with stirring at 100° C. for 15 hours. The solution was made basic with potassium carbonate and then extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off. The residual oily compound (1.22 g) was dissolved in methanol (30 ml). After fumaric acid (0.52 g) was dissolved in the solution, the solvent was distilled off to leave a solid which was recrystallized from ethanol to obtain colorless crystals (1.4 g), m.p. 199°-201° C.

Provenance & Evidence