Trifluoroacetic acid → HCID 53864130, compound

Participants

Reaction Steps

To 1-tert-Butyloxycarbonyl-4-[(4-dimethylaminophenyloxy)methyl]piperidine (0.1 g) obtained in Example 13 was added trifluoroacetic acid (0.5 ml) followed by stirring at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure, and the concentrate was diluted with methylene chloride (100 ml) and washed with aqueous saturated solution of sodium bicarbonate. The organic layer was separated, dried over sodium sulfate and concentrated under reduced pressure. The residue was treated with fumaric acid and the resulting fumarate was recrystallized from methanol to obtain 4-[(4-dimethylaminophenyloxy)methyl]piperidine 1/2 fumarate (0.1 g) as pale yellow crystals, m.p. 210°-213° C.

Provenance & Evidence