Water → HCID 23366935, compound

Participants

Reaction Steps

To a solution of 1-tert-butyloxycarbonyl-4-(4-tert-butyloxycarbonylaminophenyloxy)piperidine (0.9 g) in acetone (20 ml) were added solid potassium hydroxide (0.13 g) and 3-methyl-2-butenyl bromide (0.34 g) and the mixture was heated under reflux overnight. Water was added to the reaction mixture and the mixture was extracted with methylene chloride (50 ml×3). The combined organic layer was dried over anhydrous sodium sulfate and the solvent was distilled off. The resulting residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=4/1 (v/v)) to obtain 1-tert-butyloxycarbonyl-4-[4[N-tert-butyloxycarbonyl-N-(3-methyl-2-butenyl)amino]-phenyloxy]piperidine (0.23 g) as a colorless oil.

Provenance & Evidence