HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl hypofluorite → 4-Chloro-3,5-difluoro-2-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl hypofluorite | HCID 127602 | — |
| Reactant | 4-Chloro-5-fluoro-2-methylpyridine | HCID 19691410 | — |
| Product | 4-Chloro-3,5-difluoro-2-methylpyridine | HCID 19691230 | — |
Reaction Steps
4-Chloro-5-fluoro-2-picoline is treated with 1.1 equivalents of acetyl hypofluorite as described by O. Lerman, et al. J Org Chem, 49: 806-813 (1984) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05580872 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-e6ee433fe0d648a7844855cea4ab234f |
| Source note | uspto-grants-1996_12 |