4-Chloro-5-fluoro-2-propylpyridine → 4-Chloro-3,5-difluoro-2-propyl-pyridine

HRID 1080206Notes

Reaction equation

HRID 1080206 reaction equation
ClC1C([F:8])=CN=C(C)C=1.[Cl:10][C:11]1[C:16]([F:17])=[CH:15][N:14]=[C:13]([CH2:18][CH2:19][CH3:20])[CH:12]=1>>[Cl:10][C:11]1[C:16]([F:17])=[CH:15][N:14]=[C:13]([CH2:18][CH2:19][CH3:20])[C:12]=1[F:8]

Participants

3

Reactant 2

HCID 196912934-Chloro-5-fluoro-2-propylpyridine2×HCID 196914104-Chloro-5-fluoro-2-methylpyridine2×

Product 1

HCID 196913534-Chloro-3,5-difluoro-2-propyl-pyridine

Procedure

By following the procedures described in Example 69 and replacing 4-chloro-5-fluoro-2-picoline (the product of Example 66) with 4-chloro-5-fluoro-2-propyl-pyridine (the product of Example 70), the title compound can be prepared.

Sources & evidence

ORD record
ord-b22af62419884499abbd73896d19e98c
Source dataset
uspto-grants-1996_12
Patent number
US05580872

Reaction notes

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