HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl formate → 5-(Aminomethyl)-2-chloropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl formate | HCID 7865 | — |
| Reactant | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| Catalyst | Cobalt | HCID 104730 | — |
| Product | 5-(Aminomethyl)-2-chloropyridine | HCID 7020927 | — |
| Product | HCID 23367277 | HCID 23367277 | — |
Reaction Steps
30 g of 91.7% pure 2-chloro-5-cyanopyridine were hydrogenated in 100 ml of methylformate using 7 g of Raney cobalt analogously to Example 2. 2-Chloro-5-(formylaminomethyl)pyridine was obtained in a yield of 92.6% of theory, in addition to 2.9% of theory of 2-chloro-5-(aminomethyl)pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05580983 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-72a1f2ee673d4c368a5fe9d0a121c15c |
| Source note | uspto-grants-1996_12 |