Ammonia → 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxamide

HRID 1080398Notes

Reaction equation

HRID 1080398 reaction equation
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=O.[NH3:15]>>[C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)(=[O:2])[NH2:15]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

Product 1

HCID 537319905-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxamide

Procedure

80.6 g (0.39 mol) 3-Methoxycarbonyl-5-difluoromethoxy-1-methylpyrazole and 300 ml aqueous ammonia (33%) was stirred for one hour under reflux. The reaction solution was cooled, the precipitate suction filtered off and washed with water and diisopropyl ether.

Workup

  1. temperatureunder reflux
  2. temperatureThe reaction solution was cooled
  3. filtrationthe precipitate suction filtered off
  4. washwashed with water and diisopropyl ether

Sources & evidence

ORD record
ord-e22fd91a083f4cef96ab4fd5aa020ae9
Source dataset
uspto-grants-1996_12
Patent number
US05580986

Reaction notes

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