HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate | HCID 54319416 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole | HCID 53735123 | — |
Reaction Steps
2.1 g (10 mmol) 5-Difluoromethoxy-3-methoxycarbonyl1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmol) sulfuryl chloride and the mixture stirred at room temperature for 10 minutes. It was then concentrated and the residue recrystallised from diisopropyl ether/ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05580986 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-6eeb597d50a84789af88a1fb009e2459 |
| Source note | uspto-grants-1996_12 |