4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

HRID 108041Notes

Reaction equation

HRID 108041 reaction equation
[C:16](#[N:17])[c:18]1[cH:19][c:20]([F:37])[c:21]([O:22][CH2:23][C:24]([CH3:25])([CH3:26])[NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[cH:35][cH:36]1.[NH2:1][C:2]([CH3:3])([CH3:5])[CH2:6][O:4][c:7]1[cH:8][cH:9][c:10]([C:11]#[N:12])[cH:13][c:14]1[F:15]>>[O:4]=[CH:16][c:18]1[cH:19][c:20]([F:37])[c:21]([O:22][CH2:23][C:24]([CH3:25])([CH3:26])[NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[cH:35][cH:36]1

Participants

3

Reactant 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 86605237Tert-butyl [2-(4-cyano-2-fluorophenoxy)-1,1-dimethylethyl]carbamate

Product 1

HCID 57934591Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

Sources & evidence

ORD record
ord-2875dc8b2d274fa1876ff3fe42751b30
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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