Acetic Acid → HCID 135984214, compound

Participants

Reaction Steps

A stirred solution of 6-methoxy-3-[1-(4-pyridyl)piperazinyl]-1,2-benzisoxazole (1.75 g) and sodium ethylthiolate (0.79 g) in DMF (30 ml) was heated to 105°-107° C. under N2 for 3 hours. TLC (silica gel 30% MeOH/CH2Cl2) showed no presence of starting material. Glacial acetic acid (5 ml) was added and the solvent was removed in vacuo. The residue was flash chromatographed (silica gel) eluting with 10% MeOH/CH2Cl2 to afford 1.1 g of material. The material was further purified through recrystallization from pyridine to afford 1.0 g of the product, m.p. >250° C.

Provenance & Evidence