HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloropyrimidine → HCID 53776090, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 10988161 | HCID 10988161 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 53776090 | HCID 53776090 | 97.1% |
Reaction Steps
A stirred solution of 6-methoxy-3-(1-piperazinyl)-1,2-benzisoxazole (1.0 g), 4,6-dichloropyrimidine (0.64 g) and sodium bicarbonate (1.08 g) were refluxed in absolute ethanol under N2 for 90 minutes. TLC (silica gel 2/1 acetone/heptane) showed no presence of starting material. The reaction was allowed to cool to room temperature, partitioned between CH2Cl2 and water, extracted with CH2Cl2, dried over MgSO4 and concentrated in vacuo to afford 1.44 g of material. The material was further purified through recrystallization from CH2Cl2 /pet. ether to yield the product 1.1 g, m.p. 203°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05580982 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-d7ea5e07cf7b4fcbb5fb8e342625b26c |
| Source note | uspto-grants-1996_12 |