HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Amino-N-1H-pyrrol-1-ylcyclopentanecarboxamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | 1,1-dimethylethyl-[1-[(1H-pyrrol-1-ylamino)carbonyl]cyclopentyl]carbamate | HCID 86747437 | — |
| Solvent | Isopropanol ethyl acetate | HCID 22055037 | — |
| Product | 1-Amino-N-1H-pyrrol-1-ylcyclopentanecarboxamide Hydrochloride | HCID 19973176 | — |
Reaction Steps
To a stirred solution consisting of 1,1-dimethylethyl-[1-[(1H-pyrrol-1-ylamino)carbonyl]cyclopentyl]carbamate (2.90 g) in ethyl acetate/isopropanol (30 ml, 3:1) was added excess ethereal HCl. After stirring for 18 hours at room temperature, the reaction appeared complete by TLC (silica gel, 30% EtOAc/hexane, I2 stain). The solid was filtered under nitrogen and recrystallized from ether/methanol to afford 1.40 g of the product, m.p. 218°-220° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05580987 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-1157331bc9ba4808a119c1be1512755f |
| Source note | uspto-grants-1996_12 |