HCID 10998727, compound → HCID 10857224, compound

Participants

Reaction Steps

In a 200 ml Hastelloy autoclave was put 50 g (GC p=93.2%, 220 mmol) of methyl 4-phenyl-2-chloro-3-oxobutyrate (compound (III)), 99.4 mg (0.055 mmol) of Ru2Cl4 [(R)-T-BINAP]2NEt3, and 100 ml of isopropyl alcohol (IPA) under a nitrogen stream. After heating the solution, a hydrogen pressure of 30 atm was introduced into the autoclave at 100° C. to initiate the reaction. Then, it was confirmed by GC that no unreacted matter remained to complete the reaction (for 1 to 2 hours). IPA was recovered under reduced pressure at not higher than 50° C. to obtain 50.3 g [GC p=92.2%, HPLC o.p. syn 87% (80.5% ee), anti 13% (94.6% ee)] of compound (IV) in a yield of 98.6%.

Provenance & Evidence