Formic Acid → HCID 54053211, compound

Participants

Reaction Steps

The α-chloro-β-p-butylphenylpropionitrile 2 (166 g, 0.750 moles) was stirred over 240 mL formic acid and 160 mL concentrated HCl at reflux for 16 h. The reaction mixture was cooled, diluted with 300 mL water and washed with ethyl acetate. The ethyl acetate solution was washed with water, saturated aqueous NaCl, dried over Na2SO4, filtered and concentrated under reduced pressure. The bulk oil solidified on standing. The solid was recrystallized twice from hexane, yielding 139.0 g (0.58 moles, 77% yield) of a white solid, mp. 52.7°-53.6° C.

Provenance & Evidence