Nicotinic Acid → Zinc nicotinate

Temperature

80 °C

5.0 g of nicotinic acid was dissolved in 100 ml of deionized water with stirring in a hot bath. Similarly, 4.5 g of zinc acetate.2H2O was dissolved in 100 ml of deionized water in a hot bath, and both were mixed with vigorous stirring. Subsequently, ammonia water (1:1 mixture of 25% ammonia water and distilled water) was added to adjust the pH to 8.5. The mixture was heated in a hot bath of about 80° C. for 10 minutes to complete the reaction, was continuously applied to concentrate the mixture, then being evaporated to about 20 ml. After cooling in a refrigerator, the precipitate was filtrated with a No. 5B filter paper, and washed with deionized water. The obtained material was dissolved with heating in 200 ml of deionized water, followed by concentration to 20 ml. The concentrate was cooled at room temperature, and washed three times with deionized water. The obtained material was dried sufficiently at 65° C. in an electric oven to obtain 3.0 g of zinc nicotinate (hereinafter abbreviated as Compound A).

1. additionboth were mixed with vigorous stirring
2. customthe reaction
3. concentrationto concentrate the mixture
4. custombeing evaporated to about 20 ml
5. temperatureAfter cooling in a refrigerator
6. filtrationthe precipitate was filtrated with a No
7. filtration5B filter paper
8. washwashed with deionized water
9. dissolutionThe obtained material was dissolved
10. temperaturewith heating in 200 ml of deionized water
11. concentrationfollowed by concentration to 20 ml
12. temperatureThe concentrate was cooled at room temperature
13. washwashed three times with deionized water
14. customThe obtained material was dried sufficiently at 65° C. in an electric oven

ORD record

ord-73a62c769d434ad68c81711d9007ea6e

Source dataset

uspto-grants-1996_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05582817