HCID 178460925, compound → HCID 178460915, compound

Participants

Reaction Steps

A 15 ml THF solution of 1.5M 4-(4-fluorophenyl)phenyl magnesium bromide (22.5 mmol) was dripped into a mixed solution of 7.0 g (20.0 mmol) of trans-4-(4-iodocyclohexyl)-1-n-propyl-1-silacyclohexane, 70 mg of copper (I) iodide and 50 ml of THF. The silacyclohexane rings of the product thus obtained were a mixture of trans isomers and cis isomers. After a conventional after treatment, they were separated by means of chromatography to obtain 2.29 g (yield 58%) of the target product, i.e. the trans, trans isomers. The obtained target product exhibited the same physical properties as the product of Example 8.

Provenance & Evidence