HuagongsheHuagongshe Chemistry Print Report · For research reference only
Magnesium → HCID 178447752, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | HCID 178447741 | HCID 178447741 | — |
| Reactant | HCID 178506110 | HCID 178506110 | — |
| Catalyst | Triethyl Phosphate | HCID 6535 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178447752 | HCID 178447752 | 76.9% |
Reaction Steps
26.3 g (0.1 mol) of trans-1-bromomethyl-4-n-pentyl-4-silacyclohexane was dripped into a mixture of 2.5 g (0.11 mol) of magnesium and 300 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 500 ml THF solution of 0.5 g of triethyl phosphate, 0.1 g of copper (I) iodide and 44.4 g (0.1 mol) of 4-(trans-4-iodomethylcyclohexyl)-4'-trifluoromethylbiphenyl. After a conventional after treatment, purification was conducted by means of chromatography to obtain 38.5 g (yield 76.9%) of 4-(trans-4-(2-(trans-4-n-pentyl-4-silacyclohexyl)ethyl)cyclohexyl)-4'-trifluoromethylbiphenyl was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05582764 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-3dde35b3de12431997b75e9663eb69e1 |
| Source note | uspto-grants-1996_12 |