HCID 178460944, compound → HCID 178460943, compound

Participants

Reaction Steps

17.5 g (0.1 mol) of p-bromochlorobenzene was dripped into a mixture of 2.5 g (0.11 mol) of magnesium and 300 ml of THF to obtain a Grignard's reagent. This was dripped into a 30 ml THF solution of 13.6 g of zinc chloride to obtain an organozinc reagent. This solution was then dripped into a 500 ml THF solution of 0.5 g of tetrakis triphenylphosphine palladium and 49.2 g (0.1 mol) of 4-(trans-4-(2-(trans-4-n-propyl-4-silacyclohexyl)ethyl)cyclohexyl)-2,6-difluorophenyl iodide. After a conventional after treatment, purification was conducted by means of chromatography to obtain 27.2 g (yield 59.4%) of 4-(trans-4-(2-(trans-4-n-propyl-4-silacyclohexyl)ethyl)cyclohexyl) -2,6,4'-trifluorobiphenyl was obtained.

Provenance & Evidence