HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E,E)-5-(3beta,14beta-dihydroxy-5beta-androstane-17beta-yl)-2,4-pentadien-1-ol → (E,E)-5-(3beta,14beta-Dihydroxy-5beta-androstane-17beta-yl)-2,4-penta-dienal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E,E)-5-(3beta,14beta-dihydroxy-5beta-androstane-17beta-yl)-2,4-pentadien-1-ol | HCID 10738195 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (E,E)-5-(3beta,14beta-Dihydroxy-5beta-androstane-17beta-yl)-2,4-penta-dienal | HCID 10523343 | 98.5% |
Reaction Steps
To a solution of 4.90 g of (E,E)-5-(3β,14β-dihydroxy-5β-androstane-17β-yl)-2,4-pentadien-1-ol in 160 ml of chloroform and 40 ml of iso-propanol, 10.40 g of MnO2 were added at room temperature. The mixture was stirred overnight and then filtered through Celite. The organic solution was evaporated to dryness to give 4.80 g of the title compound (II-a) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05583127 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-fed7006946344ed4847395e87574281f |
| Source note | uspto-grants-1996_12 |