Sodium borohydride → HCID 10740169, compound

Participants

Reaction Steps

To a solution of 13.86 g of 3β-acetoxy-21-nitro-5β-pregn-20-en-14β-ol (Eberlein W. et al., Chem. Ber., 1974, 107, 1275) in 440 ml of diethyl ether and 440 ml of ethanol, 2.86 g NaBH4 were added at room temperature. After 1 hr. the mixture was neutralized with aqueous sodium dihydrogenphosphate and extracted with methylene chloride. The organic layer was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give 13.40 g of 3β-acetoxy-21-nitro-5β-pregnane-14β-ol.

Provenance & Evidence