3beta-Acetoxy-14beta-hydroxy-5beta-pregnane-21-nitrile → HCID 10782753, compound

Participants

Reaction Steps

A solution of 11.18 g of 3β-acetoxy-14β-hydroxy-5β-pregnane-21-nitrile in 260 ml of methanol, 260 ml of tetrahydrofuran and 143 ml of 1N NaOH was stirred at room temperature for 20 hrs. The mixture was then neutralized with sodium dihydrogenphosphate and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated to dryness under reduced pressure to give 8.55 g of 3β,14β-dihydroxy-5β-pregnane-21-nitrile.

Provenance & Evidence