反应详情

A mixture of 6.00 g of (E)-3β,14β-dihydroxy-5β-pregn-20-ene-21-carboxaldehyde (Fullerton D. S. and Pankaskie M. C., J. Med. Chem., 1976, 19, 1330) and 1.20 g of 5% palladium on charcoal in 1.20 l of ethanol was hydrogenated at room temperature and atmospheric pressure for 30 min. The mixture was then filtered through Celite and ethanol was evaporated to dryness to give 5.95 g of the title compound (II-c) as a white solid.

1. customwas hydrogenated at room temperature
2. filtrationThe mixture was then filtered through Celite and ethanol
3. customwas evaporated to dryness