Acetic Anhydride → HCID 86750053, compound

Participants

Reaction Steps

To a solution of 9.00 g of methyl (E)-3β,14β-dihydroxy-5β-pregn-20-ene-21-carboxylate (Boutagy J. and Thomas R., Aust. J. Pharm. Sci., 1972, NS1, 67) in 40 ml of pyridine, 0.04 g of 4-dimethylaminopyridine and 11.5 ml of acetic anhydride were added at room temperature, under nitrogen atmosphere. After 4 hrs the reaction was concentrated under reduced pressure, neutralized with aqueous sodium dihydrogenphosphate and then extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness to give 9.05 g of methyl (E)-3β-acetoxy-14β-hydroxy-5β-pregn-20-ene-21-carboxylate.

Provenance & Evidence