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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1080665Generated: October 25, 2026

Triethylamine → N-methoxyacetyl-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamin

https://huagongshe.com/reaction/1080665

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
ReactantMethoxyacetic AcidHCID 12251—
ReactantBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
Reactant2-(3-(3,4-Dichlorophenyl)-4-aminobutyl)oxytetrahydropyranHCID 15670808—
SolventDichloromethaneHCID 6344—
ProductN-methoxyacetyl-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylaminHCID 19705334—

Reaction Conditions

Temperature0 °C

Reaction Steps

A mixture of 8.6 g of 2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamine (obtained according to PREPARATION (I), step (b)), 2.46 g of methoxyacetic acid, 5.55 g of triethylamine in 50 ml of dichloromethane is cooled to 0° C. and 14.5 g of BOP is added thereto.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05583134
Source datasetuspto-grants-1996_12
ORD IDord-d869a7a1c87b484e90982da20f43cc84
Source noteuspto-grants-1996_12