反应详情

A mixture of the above 2-fluoropyridine-4-carboxylic acid (10 g) and thionyl chloride (70 mL) was heated at reflux for 25 hours. The excess thionyl chloride was removed by distillation at atmospheric pressure and the residue was distilled giving 9.51 grams of 2-fluoropyridine-4-carbonyl chloride having a boiling point of 88° C.

1. temperaturewas heated
2. temperatureat reflux for 25 hours
3. customThe excess thionyl chloride was removed by distillation at atmospheric pressure
4. distillationthe residue was distilled