HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloroisonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Pyridinecarboxylic acid, 1-oxide | HCID 26130 | — |
| Product | 2-Chloroisonicotinic acid | HCID 236985 | 72.8% |
Reaction Steps
A mixture of pyridine-4-carboxylic acid-N-oxide (28 g) and phosphorous oxychloride (120 g) was heated at reflux for 7 hours. The reaction mixture was cooled and poured into ice-water (500 mL). The precipitate was collected and crystallized from a large volume of ethyl acetate and gave 23.1 grams of 2-chloropyridine-4-carboxylic acid as a white granular solid having a melting point of 225°-227° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05583148 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-c53978d68f1b40e0adc5234cfb7189af |
| Source note | uspto-grants-1996_12 |