HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloropyridine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloroisonicotinic acid | HCID 236985 | — |
| Product | 2-Chloropyridine-4-carbonyl chloride | HCID 2800003 | — |
Reaction Steps
A solution of 2-chloropyridine-4-carboxylic acid (10 g) in thionyl chloride (90 mL) was heated under reflux for 20 hours. The excess thionyl chloride was removed by distillation at atmospheric pressure and the oily residue was distilled to give 9.26 grams of 2-chloropyridine-4-carbonyl chloride having a boiling point of 144°-148° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05583148 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-0be045e21a9b4efa84f877d272d54d19 |
| Source note | uspto-grants-1996_12 |