Thionyl Chloride → 6-Chloronicotinoyl Chloride

Participants

Reaction Steps

2-Chloropyridine-5-carboxylic acid (25 g) was dissolved in thionyl chloride (200 mL) and the mixture was heated at reflux for 24 hours. The excess thionyl chloride was removed by distillation at atmospheric pressure and the residue was distilled under reduced pressure to yield the titled compound as a clear oil (26.4 g) having a boiling point of 128°-130° C.

Provenance & Evidence