HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → Bromo(4-fluorophenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Bromo(4-fluorophenyl)acetic acid | HCID 16217752 | — |
Reaction Steps
A solution of 4-fluorophenylacetic acid (9.7 g), N-bromosuccinimide (11.2 g) and azobisisobutyronitrile (AIBN, 0.2 g) in carbontetrachloride (100 ml) was reluxed for 2 hours. After cooling it was filtered through Celite® and the filtrate was evaporated to give an oily residue of α-bromo-4-fluorophenylacetic acid, which was used for next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05583147 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-4e825495e83c42d5bb09f376aa845f60 |
| Source note | uspto-grants-1996_12 |