反应详情

The α-bromo-4-fluorophenylacetic acid from Part 1 was dissolved in methanol (100 ml) and was added Dowex-50X-400® (2.7 g) to the solution. The mixture was refluxed for 6 hours and the resin was removed by filtering through Celite® after cooling. The filtrate was evaporated to give an oily residue, which was purified by column chromatography on silica gel with elution by 1:9 ethyl acetate-hexane to afford methyl α-bromo-4-fluorophenylacetate (87% yield).

1. additionwas added Dowex-50X-400® (2.7 g) to the solution
2. temperatureThe mixture was refluxed for 6 hours
3. customthe resin was removed
4. filtrationby filtering through Celite®
5. temperatureafter cooling
6. customThe filtrate was evaporated
7. customto give an oily residue, which
8. customwas purified by column chromatography on silica gel with elution by 1:9 ethyl acetate-hexane