Lithium hydroxide, monohydrate → HCID 23365720, compound

Participants

Reaction Steps

To a stirred solution of methyl α-hexylthio-3,4-dichloro-phenylacetate (0.197 g) in tetrahydrofuran (10 ml) were added a solution of lithium hydroxide monohydrate (0.123 g) in water (10 ml) and methanol (10 ml), and the mixture was continued to stir for 2 hours at room temperature. At the end of the stirring it was evaporated to remove the organic solvents and the residue was partitioned between methylene chloride and 1N HCl. The organic layer was separated, washed with brine, dried (sodium sulfate) and evaporated to give an oily residue of α-hexylthio-3,4-dichloro-phenylacetic acid (0.179 g).

Provenance & Evidence