反应详情

To a stirred solution of 2-thiopheneglyoxylic acid (1 g) in methanol (10 ml) was added 5 drops of concentrated sufuric acid and the mixture was refluxed for 4 hours. Then the methanol was evaporated off and the residue was partitioned between ethyl acetate and water. The organic extract was washed with water and brine, dried (sodium sulfate) and evaporated to give methyl 2-thiopheneglyoxylate as an oil (1.01 g).

1. temperaturethe mixture was refluxed for 4 hours
2. customThen the methanol was evaporated off
3. customthe residue was partitioned between ethyl acetate and water
4. extractionThe organic extract
5. washwas washed with water and brine
6. dry with materialdried (sodium sulfate)
7. customevaporated