反应详情

To a stirred solution of methyl 2-thiopheneglyoxylate (1.01 g) in ethanol (20 ml) in an ice bath was added sodium borohydride (0.113 g) in 1 ml of water, and the mixture was stirred for 10 minutes. The reaction was quenched with aqueous acetic acid and the mixture was partitioned between methylene chloride and water. The organic extract was washed with brine, dried (sodium sulfate) and evaporated to give methyl α-hydroxy-2-thienylacetate as an oil (0.903 g).

1. customThe reaction was quenched with aqueous acetic acid
2. customthe mixture was partitioned between methylene chloride and water
3. extractionThe organic extract
4. washwas washed with brine
5. dry with materialdried (sodium sulfate)
6. customevaporated