HCID 12585552, compound → 142977-61-5

HRID 1080714Notes

Reaction equation

HRID 1080714 reaction equation
[F:1][C:2]([C:7]1[CH:12]=[CH:11][C:10](CC(C)C)=[CH:9][CH:8]=1)([F:6])[C:3]([OH:5])=[O:4]>C(O)(=O)C.[Pt]=O>[CH:7]1([C:2]([F:1])([F:6])[C:3]([OH:5])=[O:4])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

4

Reactant 1

HCID 12585552HCID 12585552, compound

Product 1

HCID 23365713142977-61-5Yield 115.1%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

a,α-difluoro-4-isobutyl-phenylacetic acid (900 mg, 3.9 mmol) and platinum oxide (50 mg) were suspended in acetic acid (10 ml). The mixture was hydrogenated at 50 psi for 24 hours. The mixture was filtered over celite, washed with methylene chloride, concentrated in vacuo to give 2-cyclohexyl-2,2-difluoro-acetic acid as an oil (800 mg, 88%).

Workup

  1. filtrationThe mixture was filtered over celite
  2. washwashed with methylene chloride
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-fa7461835c9c4b6f84cad020d1546bdb
Source dataset
uspto-grants-1996_12
Patent number
US05583147

Reaction notes

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