Sodium Hydroxide → HCID 23365411, compound

Participants

Reaction Steps

A solution of 5.23 g (19.8 mmol) of 4-methyl-2'-trimethylsilylethynyl-1,1'-biphenyl in 60 mL of methanol was treated with 6 mL of 1.25N aqueous sodium hydroxide. The reaction mixture was stirred at room temperature for 30 minutes and evaporated under vacuum. The residue was extracted with ether. The combined ether extracts were washed with water, dried over magnesium sulfate and evaporated under vacuum. The residue was purified by chromatography over silica gel, eluting will hexane, to yield 2.52 g (13.1 mmol, 66%) of the product. FAB-MS: calculated from C15H12 192; found 191 (M-1). 1H NMR (200 MHz, CDCl3): 2.40 (s, 3H), 5.26 (s, 1H), 7.3 (m, 8H).

Provenance & Evidence