HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → (2S-trans)-4-Methyl-2-piperidinecarboxylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | (2S,4S)-4-Methylpiperidine-2-carboxylic acid | HCID 44631639 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2S-trans)-4-Methyl-2-piperidinecarboxylic Acid Ethyl Ester | HCID 15697773 | 90% |
Reaction Steps
To a solution of dry EtOH (65 mL) and acetyl chloride (6.52 mL added dropwise at 0° C.) was added (2S, 4S)-4-methyl pipecolic acid (2.8 g, 19.6 mmol) at room temperature. The reaction was stirred at room temperature for 16 hrs and then concentrated in vacuo to give the title compound, (3.01 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05583146 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-e0ac4bac0b514f74a0c1b0ea8bdf7032 |
| Source note | uspto-grants-1996_12 |