Potassium Hydroxide → HCID 54083585, compound

HRID 1080868Notes

Reaction equation

HRID 1080868 reaction equation
[CH2:1]([O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH:16][C:17](=[O:20])[CH2:18][Cl:19])[S:14][CH:15]=1)[C:6]([O:8]CC)=[O:7])[CH3:2].[OH-].[K+]>C(O)C.O>[CH2:1]([O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH:16][C:17](=[O:20])[CH2:18][Cl:19])[S:14][CH:15]=1)[C:6]([OH:8])=[O:7])[CH3:2]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 53969068HCID 53969068, compound

Product 1

HCID 54083585HCID 54083585, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

1.06 g of ethyl α-ethoxyimino-2-(chloroacetylamino)-thiazol-4-ylacetate is suspended in a solution of 0.94 g of potassium hydroxide in a mixture of 40 ml of ethanol and 2 ml of water and the suspension is stirred at room temperature to make it to be a solution, followed by further stirring for 45 minutes at room temperature. The reaction solution is subjected to the distillation of ethanol under reduced pressure and the residue is adjusted to pH 2.0 with 1N hydrochloric acid under ice-cooling, to precipitate crystals. The crystals are filtered, washed with water and dried. The procedure yields 0.88 g of α-ethoxyimino-2-(chloroacetylamino)thiazol-4-ylacetic acid. Yield 91%.

Workup

  1. stirringby further stirring for 45 minutes at room temperature
  2. distillationThe reaction solution is subjected to the distillation of ethanol under reduced pressure
  3. temperaturecooling
  4. customto precipitate crystals
  5. filtrationThe crystals are filtered
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-41821a697cd34b85bb7d20f23aa084a7
Source dataset
uspto-grants-1996_12
Patent number
US05583216

Reaction notes

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