Phosphoric Acid → HCID 86586146, compound

HRID 10812Notes

Reaction equation

HRID 10812 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][N:27]([CH:30]([CH3:32])[CH3:31])[CH2:26][CH2:25]3)=[CH:20][CH:19]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:8].[P:33](=[O:37])([OH:36])([OH:35])[OH:34]>C(O)C>[P:33](=[O:34])([OH:37])([OH:36])[OH:35].[NH2:1][C:2]1[N:3]=[C:4]([NH:17][C:18]2[CH:19]=[CH:20][C:21]([N:24]3[CH2:25][CH2:26][N:27]([CH:30]([CH3:32])[CH3:31])[CH2:28][CH2:29]3)=[CH:22][CH:23]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:8]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 9933545HCID 9933545, compound

Product 1

HCID 86586146HCID 86586146, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of {4-amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanone (of Example 43; 113 mg, 0.25 mmol) was dissolved in hot ethanol (10 ml) and to this was added 25 mg of phosphoric acid in ethanol (1 ml). This was cooled and crystals were collected and dried to furnish {4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanone; compound with phosphoric acid. MicroAnalysis C, H, N, P, and S.

Workup

  1. temperatureThis was cooled
  2. customcrystals were collected
  3. customdried

Sources & evidence

ORD record
ord-84efb16b6cff4ea9853c2e13e6553a50
Source dataset
uspto-grants-2006_08
Patent number
US07094896B2

Reaction notes

Loading…