Imidazole → HCID 86750067, compound

HRID 1081258Notes

Reaction equation

HRID 1081258 reaction equation
[CH3:1][C:2]1([CH3:23])[C:10]2([CH3:11])[CH:5]([C:6](=[O:12])[CH2:7][CH2:8][CH2:9]2)[CH2:4][CH:3]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:22])([CH3:21])[CH3:20].[CH3:24][Si:25]([CH3:28])([CH3:27])Cl.N1C=CN=C1.N1C=CC=CC=1>C(OCC)C>[CH3:1][C:2]1([CH3:23])[C:10]2([CH3:11])[CH:5]([C:6](=[O:12])[CH2:7][CH2:8][CH2:9]2)[CH2:4][CH:3]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17][CH2:18][C:19]([CH3:21])([O:22][Si:25]([CH3:28])([CH3:27])[CH3:24])[CH3:20]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 1049PyridineHCID 6397ChlorotrimethylsilaneHCID 67705238HCID 67705238, compound

Product 1

HCID 86750067HCID 86750067, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

201 mg (0.62 mmol) of 50 is reacted with 205 mg (1.86 mmol) of trimethylchlorosilane, 167 mg (2.42 mmol) of imidazole and 0.25 ml of pyridine in 15 ml of diethyl ether analogously to 33., and 194 mg of the title compound is obtained as colorless oil.

Sources & evidence

ORD record
ord-12beb48df99345728a4df3dd748dd0a1
Source dataset
uspto-grants-1996_12
Patent number
US05585368

Reaction notes

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