HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2-nitrobenzene → N-cyclohexyl-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2-nitrobenzene | HCID 6945 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Cyclohexylamine | HCID 7965 | — |
| Product | N-cyclohexyl-2-nitroaniline | HCID 3101179 | 164.1% |
Reaction Steps
A mixture of 2-chloronitrobenzene (20 g), potassium carbonate (35 g) and copper (I) iodide (1.21 g)in cyclohexylamine (43.6 ml) was heated at 150° under nitrogen for 18 h. The mixture was allowed to cool to room temperature and was adsorbed onto silica. This was chromatographed with hexane-EA (98:2) as eluent to give the title compound (22.94 g) as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05585376 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-d5f6dc4028b845bfb81b9287b1ee1aa2 |
| Source note | uspto-grants-1996_12 |