Isatin → HCID 23363840, compound

Participants

Reaction Conditions

Reaction Steps

1H-Indole-2,3-dione (2.9 g) in dry DMF (5 ml) at 0° C. was treated with sodium hydride (80% dispersion in mineral oil, 600 mg). The mixture was warmed to 40° C. and after 45 minutes a solution of 1-(2-chloroethyl)-4-[(4-fluorophenyl)methyl]piperazine (5.1 g) in dry DMF (8 ml) was added. The reaction mixture was heated at 80° C. for 5 hours and then evaporated under reduced pressure. The residue was recrystallised twice to give 1-[2-[4-[(4-fluorophenyl)methyl]-1-piperazinyl]ethyl]-1H-indole-2,3-dione, m.p. 146°-147° C.

Provenance & Evidence