HCID 23363922, compound → HCID 23363892, compound

HRID 1081274Notes

Reaction equation

HRID 1081274 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:17][CH2:16]1)[C:8](=[O:28])[CH2:7]2)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:19][CH2:20]1)[C:8](=[O:28])[CH2:7]2

Participants

4

Reactant 1

HCID 23363922HCID 23363922, compound

Product 1

HCID 23363892HCID 23363892, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1,3-Dihydro-5-nitro-1-[2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2H-indol-2-one (200 mg) in ethanol (100 ml) containing 5% palladium on carbon (60 mg) was stirred under an atmosphere of hydrogen at STP for 1 hour. The catalyst was filtered off, the filtrate evaporated to dryness, and the residue purified by flash chromatography on silica gel.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated to dryness
  3. customthe residue purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-3eb0c22bb940449f849da71765fd8f05
Source dataset
uspto-grants-1996_12
Patent number
US05585378

Reaction notes

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